Progress Life Sciences Pvt. Ltd. is an Ethyl Oleate manufacturer, Exporter | Supplier

We are an Ethyl Oleate Manufacturer, Exporter, Supplier, Distributor, Trader and Exporter of High-Quality API, Lornoxicam, Bromhexine, Linagliptin, Sucralfate.

Our main Export in Markets, Africa, Middle East, South, Latin America, Southeast Asia, SAARC, Pakistan and Bangladesh are dealers.

active pharmaceutical ingredient list, FDA approved API list, FDA approved API manufacturers list, types of active pharmaceutical ingredients, handbook of active pharmaceutical ingredients, types of API in pharma, active pharmaceutical ingredient list, active pharmaceutical ingredient list FDA,

Looking for Ethyl oleate Manufacturer, Supplier, Exporter best in India?

Progress Life Sciences Pvt. Ltd from India Ethyl oleate manufacturer, exporter, Supplier best in the world.

Ethyl oleate is a fatty acid ester formed by the condensation of oleic acid and ethanol. It is a colorless oil although degraded samples can appear yellow.

Contents

Use and occurrence

Additive

Ethyl oleate is used by compounding pharmacies as a vehicle for intramuscular drug delivery, in some cases to prepare the daily doses of progesterone in support of pregnancy. Studies that document the safe use of ethyl oleate in pregnancy for both the mother and the fetus have never been performed. It is regulated as a food additive in the U.S. by the Food and Drug Administration.[2] Ethyl oleate is used as a solvent for pharmaceutical drug preparations involving lipophilic substances such as steroids.[3] It also finds use as a lubricant and a plasticizer. Louis Bouveault used ethyl oleate to demonstrate Bouveault–Blanc reduction, producing oleyl alcohol and ethanol,[4] a method which was subsequently refined and published in Organic Syntheses.[5]

Ethyl Oleate manufacturer

Occurrence

Ethyl oleate has been identified as a primer pheromone in honeybees.[6]

Precursor to other chemicals

By the process of ethenolysis, the methyl ester of oleic acid, converts to 1-decene and methyl 9-decenoate:[7]CH
3(CH
2)
7CH=CH(CH
2)
7CO
2Me + CH2=CH2 → CH3(CH2)7CH=CH2 + MeO2C(CH2)7CH=CH2

Medical aspects

Ethyl oleate is produced by the body during ethanol intoxication.[8] It is one of the fatty acid ethyl esters (FAEE) produced after ingestion of ethanol. Some research literature implicates FAEEs such as ethyl oleate as the toxic mediators of ethanol in the body (pancreas, liver, heart, and brain).[9][10] Ethyl oleate may be the toxic mediator of alcohol in fetal alcohol syndrome.[9] The oral ingestion of ethyl oleate has been carefully studied and due to rapid degradation in the digestive tract it appears safe for oral ingestion.[11]

See also

Ethyl oleate, 99%

Code

E 1625

Synonyms

Oleic acid ethyl ester, Ethyl (Z)-octadec-9-enoate

111-62-6

Grade for synthesis

Mol. FormulaCH3(CH2)7CH=CH(CH2)7COOC2H5

HSN Code29161590

Purity99%

Mol. Weight310.51

PackingBottle / Drum

GST Tax Rate18%

Description

Ethyl oleate is a fatty acid ester formed by the condensation of oleic acid and ethanol. It is a colorless to light yellow liquid. Ethyl oleate is produced by the body during ethanol intoxication.

Application

E 1625 (OTTO) Ethyl oleate, 99% Cas 111-62-6 – used to prepare the oily phase of self-microemulsifying drug delivery system (SMEDDS) for tacrolimus (Tac).

Properties

CategoriesUnsaturated fatty acids & derivatives

Assay98%

Appearance (Form)Liquid

Appearance (Colour)Clear pale yellow

Melting point-32 °C(lit.)

Boiling point216-218 °C

Refractive indexn20/D 1.451(lit.)

Safety Information

Safety Statements 23-24/25
WGK Germany 2
RTECS RG3715000
Flash Point(F) 235.4 °F
Flash Point(C) 113 °C

Use

Ethyl oleate should be stored in a cool, dry place in a small, wellfilled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas. Ethyl oleate oxidizes on exposure to air, resulting in an increase in the peroxide value. It remains clear at 5°C, but darkens in color on standing. Antioxidants are frequently used to extend the shelf life of ethyl oleate. Protection from oxidation for over 2 years has been achieved by storage in amber glass bottles with the addition of combinations of propyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, and citric or ascorbic acid. A concentration of 0.03% w/v of a mixture of propyl gallate (37.5%), butylated hydroxytoluene (37.5%), and butylated hydroxyanisole (25%) was found to be the best antioxidant for ethyl oleate. Ethyl oleate may be sterilized by heating at 150°C for 1 hour.